Is there any good idea for reducing alcohol intake?
“This supports other data that GABA receptors are key in the actions of alcohol and that targeting this interaction is a viable approach to reducing alcohol intake,” says David Nutt of Imperial College London, former head of the British government’s advisory committee on drugs. “Let’s hope it’s safe to use in humans.”

Other alcohol experts fear that the availability of a “sobriety pill” could encourage more, not less drinking. Markus Heilig, clinical director of the US National Institute on Alcohol Abuse and Alcoholism in Bethesda, Maryland, says that Roche abandoned development of a similar compound called Ro15-4513. “There was a lot of philosophical worry that an ‘alcohol antidote’ would entice people to consume alcohol and then count on being able to terminate the intoxicating effects on demand,” says Heilig.

Ro15-4513 caused serious side effects, including anxiety and convulsions. Liang says there is no sign that dihydromyricetin carries similar side effects.

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