What is the tetrahydropalmatine ‘s cases of poisoning?

Several cases of poisoning related to tetrahydropalmatinehave been reported.These cases involved negative effects on respiration, cardiac activity, and the nervous system. In addition, chronic hepatitis has been reported, caused by tetrahydropalmatine production in East Asia under conditions that were insufficiently sterile. Fatalities started to be reported in 1999 in cases where tetrahydropalmatine had been used in combination with other drugs having analgesic and anti-anxiety effects. All 1999 deaths could be tied to a single tetrahydropalmatine-based supplement, sold under the name "Jin Bu Huan Anodyne Tablets". This product was therefore blacklisted by US and European health authorities. In some other countries, such as Singapore, tetrahydropalmatine is treated as a controlled substance, and license is required to sell it.

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