What is the Research for Resveratrol?

There are a number of promising animal studies and some data from human clinical trials is emerging.Nevertheless, there is not enough evidence to recommend consumption of resveratrol beyond the amount that can be obtained through dietary sources, and more human clinical trials are needed.

Cancer
As of 2014, the results of limited human clinical trials with small samples sizes of the effects of resveratrol on cancer are inconsistent. Testing of resveratrol in animal models of cancer have also shown mixed results.The strongest evidence of anticancer action of resveratrol exists for tumors it can contact directly, such as skin and gastrointestinal tract tumors. For other cancers, the evidence is uncertain, even if massive doses of resveratrol are used.Resveratrol treatment appeared to prevent the development of mammary tumors in animal models; however, it had no effect on the growth of existing tumors. Paradoxically, treatment of prepubertal mice with high doses of resveratrol enhanced formation of tumors. Injected in high doses into mice, resveratrol slowed the growth of neuroblastomas.

Cardioprotective effects
Moderate drinking of red wine has long been known to reduce the risk of heart disease.This is best known as "the French paradox".

Studies suggest resveratrol in red wine may play an important role in this phenomenon.It appears to stimulate endothelial nitric oxide synthase (eNOS) activity;and inhibition of platelet aggregation.

The cardioprotective effects of resveratrol also are theorized to be a form of preconditioning—the best method of cardioprotection, rather than direct therapy.Study into the cardioprotective effects of resveratrol is based on the research of Dipak K. Das. However, he has been found guilty of scientific fraud, and many of his publications related to resveratrol have been retracted.

Antidiabetic effects
Other diabetic animal model studies by different researchers have also demonstrated the antidiabetic effects of resveratrol. This compound was shown to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2.

Skin protection
The oxidative stress induced by ultraviolet radiation is one of the main causes for premature skin ageing. The photoprotective effects of several polyphenols known for their antioxidant properties, including resveratrol, have been investigated in silico and in topical application conditions.

Neuroprotective effects
The neuroprotective effects have been confirmed in several animal model studies.

Sirtuin activation
Some of the benefits demonstrated in previous studies were overstated,however, this study was challenged immediately,and a few experiments were suggested to be of inferior quality.

Psychological

In a number of animal models resveratrol has had an antidepressant-like effect.Whether or not there is any effect in humans is unclear.

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