What are the Uses of Corosolic acid?

Corosolic acid has numerous biological properties, including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. 

What is the Dosing of Corosolic acid?

Numerous commercial formulations are available, including tablets, capsules, hypoglycemic food products, and cosmetics. Most formulations are available in capsule form, containing 18% corosolic acid and derived from Lagerstroemia speciosa L. Manufacturer suggested dosage is 1 softgel by mouth 30 minutes before morning and evening meals. Softgel products are marketed for noninsulin dependent type 2 diabetic patients.

What are the Contraindications?

Avoid use with hypersensitivity to any of the plant sources of corosolic acid.

Pregnancy/Lactation

Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.

What are the Interactions?

Counsel patients with diabetes or those taking antidiabetic medications about potential additive effects if they are self-medicating with any oral corosolic dietary supplement.

What are Adverse Reactions?

There is potential for skin rashes because the product may be derived from several plant species.

Toxicology

Toxicologic information regarding use in humans is lacking.

Corosolic acid is found in numerous plant species, including L. speciosa L., Tiarella polyphylla D. Don, Datisca cannabina L., Eriobotrya japonica (Thunb.) Lindl., and Perilla frutescens (L.) Britton.

What is the History?

Corosolic acid has numerous biological properties including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. 1 , 2 It is found in numerous plants species, particularly L. speciosa . 3 Most medical research focuses on the compound's efficacy in diabetes. Glucosol (or GlucoFit ) is a commercially available product primarily marketed in Japan and the United States as a dietary supplement for weight loss and blood sugar balance. 1 Corosolic acid is found in numerous cosmetic products, including creams, lotions, hair tonics, as well as in hypoglycemic health foods. 3 , 4 , 5

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